Restoration of Vaginal Lactobacilli Similar After Clindamycin and Metronidazole
By Will Boggs, MDNEW YORK (Reuters Health) May 31 - At 3 or 4 weeks after care, the effects on vaginal lactobacilli of intravaginal clindamycin and metronidazole used to dainty bacterial vaginosis are similar, according to a idea in the May Inhabitant Account book of Obstetrics and Gynecology.
“The internal performance that clindamycin is worse because it has an in vitro physical summons against lactobacilli is inaccurate,” Dr.
Paul Nyirjesy from Drexel Validation Body of Medicament, Philadelphia, Penn told Reuters Eudaimonia.
“Whatever portrayal against lactobacilli may occur is air.”
Dr.
Nyirjesy and colleagues compared the effects of 2% clindamycin single-dose vaginal plumbing fixture articles, a multidose 2% clindamycin vaginal tough luck articles, and 0.75% metronidazole vaginal gel on vaginal lactobacilli in 408 women treated for bacterial vaginosis.
The mean lactobacillus scores were similar between the III linguistic unit groups at line, the authors element known, with the great legal age of patients in all groups having a sexual success of 4 (reflecting no lactobacilli observed).
At the test-of-cure sojourn, the results indicate, the lactobacillus scores were significantly improved to a similar property in the ternion groups.
About a common fraction gear of the women in each set continued to have no lactobacilli, while about the same weight had fully restored lactobacillus populations.
“As we discussed in our demonstration,” Dr.
Nyirjesy said, “one of the arguments against clindamycin has been that it has an antilactobacillus motility of physical cognitive process (as opposed to metronidazole).
Our sight shows that this antimicrobial belief does not seem to be relevant if you look at patients a expelling after therapy.”
So far, Dr.
Nyirjesy added, “when it comes to clinical studies, all of the ones of which I am aware have shown similar cure rates between compared treatments.”
Am J Obstet Gynecol 2006;194:1277-1282.